ZFY

Across TCGA patient cohorts, ZFY protein abundance is significantly associated with the RNA expression of many other genes, with 115 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZFY-associated genes across cancer lineages are SGSM3, ATP6V1D, and STS. Each is linked with ZFY in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFY-to-partner and partner-to-ZFY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZFY versus SGSM3 in GBM, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFY→partner) and Y-score (partner→ZFY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SGSM3 →	+0.351	+0.586	.001	.001	3	1
GBM	ATP6V1D →	-0.539	-0.809	<.001	.001	3	1
GBM	STS →	-0.853	-0.809	<.001	.001	3	1
GBM	SKP1 →	-0.443	-0.585	.002	.001	3	1
GBM	C5orf15 →	-0.635	-0.585	<.001	.001	3	1
GBM	RBP1 →	-2.378	-0.586	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

ZFY vs SGSM3 — GBM

Explore this scatter interactively →