ZFY

Across TCGA patient cohorts, ZFY mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible ZFY-associated genes across cancer lineages are RN7SKP179, MRGPRX9P, and MIR3908. Each is linked with ZFY in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFY-to-partner and partner-to-ZFY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP179 grouped by ZFY-low versus ZFY-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFY→partner) and Y-score (partner→ZFY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP179 →	+0.199	+4.979	<.001	.009	3	1
SKCM	MRGPRX9P →	+0.090	+6.328	<.001	.001	3	1
SKCM	MIR3908 →	+0.431	+5.970	<.001	.002	3	1
BLCA	OR7E129P →	+0.088	+3.719	<.001	.008	3	1
BLCA	RN7SKP104 →	+0.099	+5.722	<.001	.001	3	1
BLCA	RNA5SP205 →	+0.297	+5.229	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

RN7SKP179 by ZFY expression — SKCM

Explore this box plot interactively →