ZFX

Across TCGA pan-cancer cohorts, ZFX mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZFX’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ZFX mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZFX is over-expressed in tumor.

LUAD, HNSC, and CCRCC are the cancer types where ZFX tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFX mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+0.618	<.001	8	view →
HNSC	All	All	+0.314	.004	6	view →
CCRCC	Female	All	+0.449	.004	4	view →
LSCC	All	All	+0.364	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZFX–LUAD

Open the LUAD breakdown →