ZFR2

Across TCGA patient cohorts, ZFR2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFR2-associated genes across cancer lineages are PDCD4, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with ZFR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZFR2-to-partner and partner-to-ZFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ZFR2-low versus ZFR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFR2→partner) and Y-score (partner→ZFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.554	-3.169	.005	.018	3	3
COAD	Caspase-7-cleavedD198 →	+0.824	+3.330	.026	.005	3	3
UCEC	EGFR_pY1068 →	-0.248	-1.700	.019	.044	3	2
UCEC	ERK2 →	+0.264	+2.222	.001	.011	3	2
UCEC	ASNS →	+0.307	+1.700	.045	.044	3	2
UCEC	C-Raf →	+0.174	+3.321	.004	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PDCD4 by ZFR2 expression — UCEC

Explore this box plot interactively →