ZFR

Across TCGA patient cohorts, ZFR mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFR-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and FoxM1. Each is linked with ZFR in more than 3 cancer types. Because this analysis shows association rather than direction, both ZFR-to-partner and partner-to-ZFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZFR-low versus ZFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFR→partner) and Y-score (partner→ZFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.112	-1.643	.014	.010	3	4
UCEC	Caspase-7-cleavedD198 →	+0.780	+2.662	<.001	<.001	3	4
UCEC	FoxM1 →	+0.177	+1.263	.025	.019	3	3
COAD	GAPDH →	+0.860	+3.008	.001	.019	3	3
UCEC	eEF2 →	+0.277	+1.263	.011	.019	3	2
UCEC	FOXO3a_pS318_S321 →	-0.090	-1.212	.018	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

mTOR_pS2448 by ZFR expression — UCEC

Explore this box plot interactively →