ZFR

Across TCGA cell cohorts, ZFR mutation is significantly associated with the RNA expression of many other genes, with 371 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZFR-associated genes across cancer lineages are RPTN, C16orf90, and LYZL6. Each is linked with ZFR in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFR-to-partner and partner-to-ZFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPTN grouped by ZFR-low versus ZFR-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFR→partner) and Y-score (partner→ZFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPTN →	+0.058	+3.884	<.001	.005	3	2
URINARY_TRACT	C16orf90 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	LYZL6 →	+0.082	+4.217	.002	.005	3	1
LUNG_SCLC	GZMK →	+0.033	+4.070	<.001	.003	3	1
LUNG_SCLC	TMEM174 →	+0.049	+3.523	<.001	.008	3	1
LUNG_SCLC	TMEM239 →	+0.065	+4.459	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 371 associations by consensus.

RPTN by ZFR expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →