ZFPL1

Across TCGA patient cohorts, ZFPL1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFPL1-associated genes across cancer lineages are eIF4E, ETS-1, and GATA3. Each is linked with ZFPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFPL1-to-partner and partner-to-ZFPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZFPL1-low versus ZFPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFPL1→partner) and Y-score (partner→ZFPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.226	+2.000	.017	.032	3	1
UCEC	ETS-1 →	-0.389	-2.000	.006	.032	3	1
UCEC	GATA3 →	-0.225	-1.986	.008	.032	3	1
UCEC	Ku80 →	+0.262	+1.884	.013	.030	3	1
UCEC	N-Cadherin →	-0.288	-1.990	.002	.030	3	1
UCEC	NF2 →	-0.213	-2.700	.029	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by ZFPL1 expression — UCEC

Explore this box plot interactively →