ZFPL1

Across TCGA cell cohorts, ZFPL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,682 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZFPL1-associated GO terms across cancer lineages are Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, and Protein exit from endoplasmic reticulum. Each is linked with ZFPL1 in more than 16 cancer types. Because this analysis shows association rather than direction, both ZFPL1-to-partner and partner-to-ZFPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway grouped by ZFPL1-low versus ZFPL1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFPL1→partner) and Y-score (partner→ZFPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.154	+0.671	<.001	<.001	3	17
BONE	Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.174	+0.964	<.001	<.001	3	13
BLOOD_Lymphoma	Protein exit from endoplasmic reticulum →	+0.161	+0.716	<.001	<.001	3	13
KIDNEY	Negative regulation of response to endoplasmic reticulum stress →	+0.116	+0.682	<.001	.003	3	12
BLOOD_Lymphoma	Endoplasmic reticulum to cytosol transport →	+0.165	+0.698	<.001	<.001	3	12
BLOOD_Lymphoma	Retrograde protein transport, ER to cytosol →	+0.165	+0.698	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,682 associations by consensus.

Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway by ZFPL1 expression — BONE

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