ZFP64

Across TCGA pan-cancer cohorts, ZFP64 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated ZFP64 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ZFP64 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZFP64 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

READ, BRCA, and ACC are the cancer types where ZFP64 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	33	view →
BRCA	OS	Median	III,IV	0.466	0.836	<.001	20	view →
ACC	DFS	Median	All	0.057	0.623	.001	18	view →
UCEC	DFS	Median	All	0.955	0.614	.005	12	view →
STAD	DFS	Median	All	0.896	0.642	.014	12	view →
LIHC	OS	Median	All	0.031	0.775	<.001	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
LUAD	OS	Median	All	0.112	0.363	.011	8	view →
HNSC	DFS	Median	III,IV	0.170	0.610	.048	3	view →
SKCM	OS	Median	All	0.166	0.337	.004	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

ZFP64–READ (OS)

Open the READ breakdown →