ZFP64

Across TCGA pan-cancer cohorts, ZFP64 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZFP64 data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZFP64 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZFP64 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where ZFP64 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.555	0.877	.001	49	view →
UCEC	DFS	Median	II,III,IV	0.500	0.926	.006	10	view →
PDAC	OS	Quartile	II,III,IV	0.437	0.763	.027	6	view →
CCRCC	DFS	Median	IV	0.932	0.382	.031	4	view →
GBM	OS	Tertile	All	0.512	0.290	.015	3	view →
LSCC	DFS	Median	All	0.976	0.896	.006	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZFP64–HNSC (DFS)

Open the HNSC breakdown →