Across TCGA patient cohorts, ZFP57 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFP57-associated genes across cancer lineages are p62 Lck ligand, mTOR_pS2448, and Notch1. Each is linked with ZFP57 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZFP57-to-partner and partner-to-ZFP57 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP57→partner) and Y-score (partner→ZFP57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.439	+2.247	<.001	.001	3	3
UCEC	mTOR_pS2448 →	-0.179	-2.687	.001	.005	3	2
UCEC	Notch1 →	+0.212	+2.331	<.001	.003	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.416	-1.906	.011	.015	3	2
UCEC	CD49b →	-0.286	-2.302	.006	.005	3	2
SKCM	4E-BP1 →	+0.313	+3.000	.031	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

ZFP57 survival (RNA) · tumor vs normal (RNA) · all ZFP57 data types