ZFP42

Across TCGA pan-cancer cohorts, ZFP42 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZFP42 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZFP42 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZFP42 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, KIRC, and BRCA are the cancer types where ZFP42 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.475	.007	32	view →
KIRC	OS	Median	All	0.172	0.811	.002	12	view →
BRCA	OS	Median	All	0.573	0.963	.007	8	view →
PRAD	DFS	Median	All	0.617	0.886	.027	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZFP42–UCEC (DFS)

Open the UCEC breakdown →