ZFP37

Across TCGA patient cohorts, ZFP37 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFP37-associated genes across cancer lineages are Gab2, Smac, and Caspase-7-cleavedD198. Each is linked with ZFP37 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFP37-to-partner and partner-to-ZFP37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by ZFP37-low versus ZFP37-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP37→partner) and Y-score (partner→ZFP37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Gab2 →	+0.350	+3.000	.020	.036	3	2
BLCA	Smac →	+0.297	+3.017	.028	.019	3	2
LUSC	Caspase-7-cleavedD198 →	+0.809	+2.816	.003	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.200	-2.584	<.001	.001	3	2
UCEC	PCNA →	+0.278	+2.523	<.001	<.001	3	2
UCEC	ASNS →	+0.537	+2.321	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Gab2 by ZFP37 expression — BLCA

Explore this box plot interactively →