ZFP37

Across TCGA cell cohorts, ZFP37 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZFP37-associated genes across cancer lineages are OR10A5, IL22, and SPATA48. Each is linked with ZFP37 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFP37-to-partner and partner-to-ZFP37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A5 grouped by ZFP37-low versus ZFP37-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP37→partner) and Y-score (partner→ZFP37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR10A5 →	+0.015	+2.925	.001	.003	3	2
STOMACH	IL22 →	+0.046	+5.285	<.001	.003	3	1
STOMACH	SPATA48 →	+0.006	+5.285	<.001	.003	3	1
STOMACH	LRRC72 →	+0.093	+5.285	<.001	.003	3	1
BLOOD_Lymphoma	OR14A16 →	+0.016	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP4-11 →	+0.038	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

OR10A5 by ZFP37 expression — CNS

Explore this box plot interactively →