ZFP36

Across TCGA pan-cancer cohorts, ZFP36 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZFP36 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZFP36 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZFP36 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, HNSC, and GBM are the cancer types where ZFP36 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.321	0.823	.001	50	view →
HNSC	DFS	Tertile	All	0.812	0.566	.015	8	view →
GBM	DFS	Median	All	0.364	1.000	.014	6	view →
CCRCC	DFS	Tertile	III,IV	0.295	0.803	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZFP36–LUAD (OS)

Open the LUAD breakdown →