ZFP30

Across TCGA cell cohorts, ZFP30 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,882 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZFP30-associated GO terms across cancer lineages are Regulation of heterochromatin formation, Regulation of chromosome segregation, and Regulation of heterochromatin organization. Each is linked with ZFP30 in more than 11 cancer types. Because this analysis shows association rather than direction, both ZFP30-to-partner and partner-to-ZFP30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heterochromatin formation grouped by ZFP30-low versus ZFP30-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP30→partner) and Y-score (partner→ZFP30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of heterochromatin formation →	+0.183	+1.299	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Regulation of chromosome segregation →	+0.102	+1.740	<.001	<.001	3	12
LUNG_SCLC	Regulation of heterochromatin organization →	+0.166	+1.059	<.001	<.001	3	11
OVARY	Negative regulation of heterochromatin organization →	+0.122	+1.482	<.001	<.001	3	11
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.077	+1.012	<.001	<.001	3	11
LUNG_SCLC	Regulation of nucleotide-excision repair →	+0.138	+0.983	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,882 associations by consensus.

Regulation of heterochromatin formation by ZFP30 expression — LUNG_SCLC

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