ZFP14

Across TCGA patient cohorts, ZFP14 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFP14-associated genes across cancer lineages are ERK2, Ku80, and C-Raf. Each is linked with ZFP14 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZFP14-to-partner and partner-to-ZFP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ZFP14-low versus ZFP14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP14→partner) and Y-score (partner→ZFP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.178	+2.222	.007	.009	3	3
SKCM	Ku80 →	+0.350	+3.169	.020	.019	3	2
SKCM	C-Raf →	+0.178	+3.169	.018	.019	3	2
UCEC	Myosin-IIa_pS1943 →	+0.154	+1.700	.031	.042	3	2
UCEC	PDCD4 →	-0.454	-2.584	.005	.010	3	2
UCEC	Annexin-1 →	+0.429	+1.604	.018	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ERK2 by ZFP14 expression — UCEC

Explore this box plot interactively →