ZFHX4

Across TCGA pan-cancer cohorts, ZFHX4 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated ZFHX4 data layer compared with 28 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher ZFHX4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZFHX4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

THYM, UCEC, and DLBC are the cancer types where ZFHX4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.931	0.814	.001	32	view →
DLBC	OS	Median	III,IV	0.172	0.907	<.001	30	view →
UCS	DFS	Median	All	0.090	0.532	<.001	18	view →
HNSC	DFS	Median	II,III,IV	0.316	0.678	.005	16	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ESCA	DFS	Median	All	0.205	0.425	.002	12	view →
SCLC	DFS	Median	III,IV	0.863	0.233	.017	6	view →
SARC	DFS	Median	All	0.219	0.638	.007	5	view →
KIRC	DFS	Median	All	0.295	0.639	.018	4	view →
KIRP	OS	Median	All	0.135	0.703	.040	3	view →
COAD	OS	Median	IV	0.324	0.693	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

ZFHX4–THYM (OS)

Open the THYM breakdown →