ZFHX4

Across TCGA pan-cancer cohorts, ZFHX4 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZFHX4 data layer compared with 28 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZFHX4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZFHX4 expression acts as an unfavorable survival marker.

PDAC and LSCC are the cancer types where ZFHX4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.173	0.904	.017	18	view →
LSCC	DFS	Quartile	All	0.198	0.887	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ZFHX4–PDAC (DFS)

Open the PDAC breakdown →