ZFHX4

Across TCGA patient cohorts, ZFHX4 mutation is significantly associated with the RNA expression of many other genes, with 9,795 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFHX4-associated genes across cancer lineages are SKA1, MCM10, and MCM6. Each is linked with ZFHX4 in more than 7 cancer types. Because this analysis shows association rather than direction, both ZFHX4-to-partner and partner-to-ZFHX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by ZFHX4-low versus ZFHX4-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX4→partner) and Y-score (partner→ZFHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SKA1 →	+0.976	+3.815	.002	<.001	3	8
LUAD	MCM10 →	+0.549	+1.834	<.001	<.001	3	8
LUAD	MCM6 →	+0.372	+1.059	<.001	<.001	3	7
LIHC	BIRC5 →	+1.157	+3.333	.003	.005	2	8
LIHC	HMBS →	+0.616	+3.568	<.001	.001	3	7
LUAD	MELK →	+0.605	+0.877	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,795 associations by consensus.

SKA1 by ZFHX4 expression — LIHC

Explore this box plot interactively →