ZFHX4

Across TCGA patient cohorts, ZFHX4 mutation is significantly associated with the total protein of many other genes, with 118 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFHX4-associated genes across cancer lineages are INPP4B, Chk2_pT68, and eIF4E. Each is linked with ZFHX4 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZFHX4-to-partner and partner-to-ZFHX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ZFHX4-low versus ZFHX4-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX4→partner) and Y-score (partner→ZFHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	INPP4B →	-0.294	-2.951	.001	.034	3	6
BLCA	Chk2_pT68 →	+0.119	+1.263	.005	.017	3	5
STAD	eIF4E →	+0.109	+1.064	.031	.042	3	5
STAD	PCNA →	+0.224	+1.765	.005	.010	3	5
STAD	CD49b →	+0.197	+1.502	.020	.024	3	5
STAD	4E-BP1 →	+0.261	+3.000	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 118 associations by consensus.

INPP4B by ZFHX4 expression — LIHC

Explore this box plot interactively →