ZFHX4

Across TCGA cell cohorts, ZFHX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,981 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible ZFHX4-associated GO terms across cancer lineages are Establishment of mitotic spindle localization, Positive regulation of post-translational protein modification, and Cytoplasmic translation. Each is linked with ZFHX4 in more than 10 cancer types. Because this analysis shows association rather than direction, both ZFHX4-to-partner and partner-to-ZFHX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of mitotic spindle localization grouped by ZFHX4-low versus ZFHX4-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX4→partner) and Y-score (partner→ZFHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Establishment of mitotic spindle localization →	+0.114	+2.204	.002	.006	3	11
OVARY	Positive regulation of post-translational protein modification →	+0.057	+1.204	<.001	<.001	3	11
OESOPHAGUS	Cytoplasmic translation →	+0.126	+0.995	.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of blood circulation →	-0.090	-0.956	.001	.004	3	11
LIVER	Transcription initiation at RNA polymerase II promoter →	+0.073	+2.147	<.001	<.001	3	11
LIVER	DNA-templated transcription initiation →	+0.085	+2.456	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,981 associations by consensus.

Establishment of mitotic spindle localization by ZFHX4 expression — LIVER

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