ZFHX4

Across TCGA cell cohorts, ZFHX4 mutation is significantly associated with the RNA expression of many other genes, with 1,626 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZFHX4-associated genes across cancer lineages are HINT1, PSMG2, and STX16. Each is linked with ZFHX4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZFHX4-to-partner and partner-to-ZFHX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HINT1 grouped by ZFHX4-low versus ZFHX4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX4→partner) and Y-score (partner→ZFHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HINT1 →	+0.442	+3.518	<.001	<.001	3	4
SKIN	PSMG2 →	+0.442	+2.667	<.001	<.001	3	4
SKIN	STX16 →	-0.594	-1.584	<.001	.005	3	3
BREAST	TMEM91 →	-0.512	-2.385	.006	.005	3	3
SKIN	ZMYND8 →	-0.602	-1.541	<.001	.001	3	3
BLOOD_Leukemia	CD68 →	-1.795	-2.069	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,626 associations by consensus.

HINT1 by ZFHX4 expression — BLOOD_Leukemia

Explore this box plot interactively →