ZFHX3

Across TCGA patient cohorts, ZFHX3 mutation is significantly associated with the total protein of many other genes, with 108 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFHX3-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and CD49b. Each is linked with ZFHX3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZFHX3-to-partner and partner-to-ZFHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZFHX3-low versus ZFHX3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX3→partner) and Y-score (partner→ZFHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.002	+1.645	<.001	<.001	3	6
UCEC	ATM →	-0.466	-1.115	<.001	<.001	3	5
STAD	CD49b →	+0.279	+2.807	.008	.002	3	5
COAD	mTOR_pS2448 →	-0.119	-2.098	.012	.015	3	5
LUSC	Tuberin →	-0.351	-3.321	.001	.009	3	4
LUSC	Bad_pS112 →	-0.122	-2.059	.038	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

Caspase-7-cleavedD198 by ZFHX3 expression — COAD

Explore this box plot interactively →