ZFHX3

Across TCGA cell cohorts, ZFHX3 mutation is significantly associated with the RNA expression of many other genes, with 1,261 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZFHX3-associated genes across cancer lineages are GDPGP1, FBXO47, and GOLM2. Each is linked with ZFHX3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZFHX3-to-partner and partner-to-ZFHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDPGP1 grouped by ZFHX3-low versus ZFHX3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX3→partner) and Y-score (partner→ZFHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GDPGP1 →	+0.612	+2.655	.002	<.001	3	4
BLOOD_Myeloma	FBXO47 →	+0.048	+3.584	<.001	.006	3	3
LARGE_INTESTINE	GOLM2 →	+0.562	+2.807	.001	<.001	3	3
STOMACH	ZNF77 →	+0.543	+1.944	.007	.008	3	3
STOMACH	SLC39A9 →	+0.488	+3.289	<.001	<.001	3	3
SKIN	NSUN6 →	+0.591	+3.212	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,261 associations by consensus.

GDPGP1 by ZFHX3 expression — STOMACH

Explore this box plot interactively →