ZFHX2

Across TCGA patient cohorts, ZFHX2 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFHX2-associated genes across cancer lineages are A-Raf_pS299, GAPDH, and PDCD4. Each is linked with ZFHX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFHX2-to-partner and partner-to-ZFHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ZFHX2-low versus ZFHX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX2→partner) and Y-score (partner→ZFHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.128	-2.321	<.001	<.001	3	2
UCEC	GAPDH →	+0.372	+2.087	.021	.004	3	2
UCEC	PDCD4 →	-0.389	-1.125	.006	.033	3	2
UCEC	ATM →	-0.439	-3.794	.001	<.001	3	2
UCEC	Beclin →	-0.059	-1.584	.038	.032	3	2
UCEC	Chk2_pT68 →	-0.165	-2.295	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

A-Raf_pS299 by ZFHX2 expression — UCEC

Explore this box plot interactively →