ZFHX2

Across TCGA cell cohorts, ZFHX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,658 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZFHX2-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Heterochromatin formation, and Nucleosome organization. Each is linked with ZFHX2 in more than 12 cancer types. Because this analysis shows association rather than direction, both ZFHX2-to-partner and partner-to-ZFHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by ZFHX2-low versus ZFHX2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX2→partner) and Y-score (partner→ZFHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.079	+1.257	<.001	<.001	3	13
STOMACH	Heterochromatin formation →	+0.093	+0.935	<.001	<.001	3	13
LUNG_SCLC	Nucleosome organization →	+0.104	+1.179	<.001	<.001	3	13
STOMACH	Negative regulation of gene expression, epigenetic →	+0.083	+0.882	.001	.001	2	13
STOMACH	Heterochromatin organization →	+0.093	+1.023	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.062	+0.514	.007	.007	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,658 associations by consensus.

Epigenetic regulation of gene expression by ZFHX2 expression — LUNG_SCLC

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