ZFHX2

Across TCGA cell cohorts, ZFHX2 mutation is significantly associated with the RNA expression of many other genes, with 2,097 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZFHX2-associated genes across cancer lineages are PHOX2B, FAM162B, and KRTAP2-1. Each is linked with ZFHX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFHX2-to-partner and partner-to-ZFHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by ZFHX2-low versus ZFHX2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFHX2→partner) and Y-score (partner→ZFHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PHOX2B →	+0.019	+4.643	<.001	.008	3	2
SOFT_TISSUE	FAM162B →	+1.282	+3.706	<.001	.005	3	2
SOFT_TISSUE	KRTAP2-1 →	+0.070	+3.832	.002	.001	3	2
STOMACH	DBX2 →	+0.031	+4.280	<.001	.001	3	2
SKIN	RPL10A →	+0.539	+2.743	<.001	.001	3	2
BLOOD_Leukemia	PTPN5 →	+0.402	+3.934	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,097 associations by consensus.

PHOX2B by ZFHX2 expression — URINARY_TRACT

Explore this box plot interactively →