ZFAT

Across TCGA patient cohorts, ZFAT mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFAT-associated genes across cancer lineages are ATM, 4E-BP1_pT70, and Akt. Each is linked with ZFAT in more than 3 cancer types. Because this analysis shows association rather than direction, both ZFAT-to-partner and partner-to-ZFAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZFAT-low versus ZFAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFAT→partner) and Y-score (partner→ZFAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.403	-1.986	.001	.008	3	4
LUSC	4E-BP1_pT70 →	+0.232	+2.179	.020	.035	3	3
COAD	Akt →	-0.431	-3.321	.021	.009	3	3
UCEC	ASNS →	+0.350	+1.925	<.001	.004	3	3
COAD	YB-1 →	-0.427	-1.991	.011	.031	3	2
SKCM	CD31 →	-0.144	-2.000	.013	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

ATM by ZFAT expression — UCEC

Explore this box plot interactively →