ZFAT

Across TCGA cell cohorts, ZFAT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,160 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZFAT-associated GO terms across cancer lineages are mRNA alternative polyadenylation, Regulation of protein sumoylation, and Protein destabilization. Each is linked with ZFAT in more than 10 cancer types. Because this analysis shows association rather than direction, both ZFAT-to-partner and partner-to-ZFAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA alternative polyadenylation grouped by ZFAT-low versus ZFAT-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFAT→partner) and Y-score (partner→ZFAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	mRNA alternative polyadenylation →	+0.112	+0.699	<.001	<.001	3	10
URINARY_TRACT	Regulation of protein sumoylation →	+0.129	+0.727	<.001	.001	2	11
SKIN	Protein destabilization →	+0.039	+0.394	.008	.001	3	10
LIVER	Transcription initiation at RNA polymerase II promoter →	+0.081	+0.557	<.001	.003	3	10
STOMACH	miRNA processing →	+0.121	+1.047	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of transcription initiation by RNA polymerase II →	+0.060	+0.684	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,160 associations by consensus.

mRNA alternative polyadenylation by ZFAT expression — BONE

Explore this box plot interactively →