ZFAT-AS1

Across TCGA pan-cancer cohorts, ZFAT-AS1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated ZFAT-AS1 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ZFAT-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZFAT-AS1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

READ, UCEC, and UVM are the cancer types where ZFAT-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	All	0.274	0.827	<.001	105	view →
UCEC	DFS	Tertile	All	0.128	0.659	<.001	66	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	48	view →
ACC	DFS	Tertile	All	0.105	0.673	.001	36	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	27	view →
LUSC	OS	Tertile	III,IV	0.054	0.768	<.001	18	view →
THCA	OS	Tertile	IV	0.626	1.000	.002	18	view →
TGCT	OS	Tertile	All	0.767	0.968	.002	18	view →
KICH	DFS	Tertile	All	0.162	0.862	.014	15	view →
ESCA	DFS	Tertile	II,III,IV	0.394	0.561	.028	13	view →
GBM	OS	Tertile	All	0.663	0.379	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ZFAT-AS1–READ (OS)

Open the READ breakdown →