ZFAND6

Across TCGA patient cohorts, ZFAND6 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFAND6-associated genes across cancer lineages are 14-3-3_beta, ACVRL1, and JNK_pT183_Y185. Each is linked with ZFAND6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFAND6-to-partner and partner-to-ZFAND6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ZFAND6-low versus ZFAND6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFAND6→partner) and Y-score (partner→ZFAND6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.115	-2.986	.048	.037	3	1
UCEC	ACVRL1 →	-0.170	-2.980	.030	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.236	-2.986	.015	.037	3	1
UCEC	Ku80 →	+0.374	+3.013	.006	.019	3	1
UCEC	Src_pY416 →	-0.325	-2.986	.019	.037	3	1
UCEC	C-Raf →	+0.214	+3.000	.009	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

14-3-3_beta by ZFAND6 expression — UCEC

Explore this box plot interactively →