ZFAND4

Across TCGA patient cohorts, ZFAND4 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFAND4-associated genes across cancer lineages are MEK1, PDCD4, and ATM. Each is linked with ZFAND4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFAND4-to-partner and partner-to-ZFAND4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZFAND4-low versus ZFAND4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFAND4→partner) and Y-score (partner→ZFAND4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.330	+1.700	.003	.001	3	2
UCEC	PDCD4 →	-0.502	-2.222	<.001	.009	3	2
UCEC	ATM →	-0.388	-1.765	.005	.013	3	2
UCEC	4E-BP1 →	+0.312	+1.947	<.001	<.001	3	2
UCEC	C-Raf →	+0.116	+1.584	.008	.017	3	2
SKCM	PI3K-p85 →	+0.211	+2.182	.037	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

MEK1 by ZFAND4 expression — UCEC

Explore this box plot interactively →