ZFAND3

Across TCGA pan-cancer cohorts, ZFAND3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZFAND3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZFAND3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZFAND3 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, LIHC, and BRCA are the cancer types where ZFAND3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFAND3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.737	<.001	12	view →
LIHC	Female	II,III,IV	+1.083	<.001	9	view →
BRCA	All	III,IV	+0.401	<.001	8	view →
THCA	All	All	−0.328	<.001	8	view →
CHOL	All	All	+1.456	<.001	5	view →
LUSC	All	All	+0.247	.002	4	view →
KIRC	Male	II,III,IV	−0.313	.005	3	view →
LUAD	All	II,III,IV	+0.289	.005	3	view →
KIRP	Female	II,III,IV	+0.722	.048	2	view →
KICH	Male	All	−0.689	.005	2	view →
READ	All	All	−0.353	.017	2	view →
ESCA	Female	All	+0.783	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZFAND3–HNSC

Open the HNSC breakdown →