ZFAND2B

Across TCGA pan-cancer cohorts, ZFAND2B mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ZFAND2B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZFAND2B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZFAND2B is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where ZFAND2B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFAND2B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.463	<.001	8	view →
HNSC	All	IV	−0.422	<.001	8	view →
LSCC	Male	III,IV	−0.409	<.001	8	view →
CCRCC	All	All	−0.152	<.001	8	view →
PDAC	All	All	+0.223	.037	3	view →
LUAD	All	All	−0.062	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ZFAND2B–COAD

Open the COAD breakdown →