ZER1

Across TCGA patient cohorts, ZER1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZER1-associated genes across cancer lineages are eIF4E, MEK1, and Notch1. Each is linked with ZER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZER1-to-partner and partner-to-ZER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZER1-low versus ZER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZER1→partner) and Y-score (partner→ZER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.160	+2.584	.023	.010	3	2
UCEC	MEK1 →	+0.375	+2.201	.002	<.001	3	2
UCEC	Notch1 →	+0.207	+3.058	<.001	<.001	3	2
UCEC	ATM →	-0.430	-1.874	.004	.002	3	2
UCEC	4E-BP1 →	+0.264	+1.874	.003	.002	3	2
UCEC	eIF4G →	+0.269	+2.321	.009	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by ZER1 expression — UCEC

Explore this box plot interactively →