ZER1

Across TCGA cell cohorts, ZER1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,554 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ZER1-associated GO terms across cancer lineages are Positive regulation of autophagy, Regulation of macroautophagy, and Positive regulation of vacuole organization. Each is linked with ZER1 in more than 18 cancer types. Because this analysis shows association rather than direction, both ZER1-to-partner and partner-to-ZER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of autophagy grouped by ZER1-low versus ZER1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZER1→partner) and Y-score (partner→ZER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.061	+0.924	<.001	<.001	3	19
OESOPHAGUS	Regulation of macroautophagy →	+0.094	+1.497	<.001	<.001	3	18
STOMACH	Positive regulation of vacuole organization →	+0.103	+1.136	<.001	<.001	3	18
STOMACH	Negative regulation of autophagy →	+0.093	+1.439	<.001	<.001	3	18
STOMACH	Autophagy of mitochondrion →	+0.110	+1.504	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.077	+1.254	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,554 associations by consensus.

Positive regulation of autophagy by ZER1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →