ZER1

Across TCGA cell cohorts, ZER1 mutation is significantly associated with the RNA expression of many other genes, with 240 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZER1-associated genes across cancer lineages are INPP5K, PRH2, and GATAD2B. Each is linked with ZER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZER1-to-partner and partner-to-ZER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP5K grouped by ZER1-low versus ZER1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZER1→partner) and Y-score (partner→ZER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	INPP5K →	+0.774	+3.064	<.001	.009	3	2
BLOOD_Leukemia	PRH2 →	+0.160	+3.517	<.001	.005	3	2
BLOOD_Leukemia	GATAD2B →	+0.717	+3.120	.001	.009	3	2
BLOOD_Lymphoma	BIRC8 →	+0.005	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	FAM187B →	+0.044	+4.643	<.001	.005	3	1
LARGE_INTESTINE	TAB1 →	+0.667	+3.067	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 240 associations by consensus.

INPP5K by ZER1 expression — LARGE_INTESTINE

Explore this box plot interactively →