ZEB1

Across TCGA patient cohorts, ZEB1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,859 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ZEB1-associated genes across cancer lineages are LHFPL6, RECK, and JAM3. Each is linked with ZEB1 in more than 8 cancer types. Because this analysis shows association rather than direction, both ZEB1-to-partner and partner-to-ZEB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZEB1 versus LHFPL6 in OV, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZEB1→partner) and Y-score (partner→ZEB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LHFPL6 →	+1.119	+0.965	.007	.003	3	9
BRCA	RECK →	+1.031	+0.594	<.001	<.001	3	7
BRCA	JAM3 →	+1.021	+0.601	<.001	<.001	3	7
BRCA	F2R →	+1.080	+0.482	<.001	<.001	3	7
CCRCC	PRKG1 →	+1.121	+0.436	<.001	.003	3	7
BRCA	KANK2 →	+0.881	+0.437	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,859 associations by consensus.

ZEB1 vs LHFPL6 — OV

Explore this scatter interactively →