ZEB1

Across TCGA cell cohorts, ZEB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,137 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZEB1-associated GO terms across cancer lineages are Negative regulation of microtubule depolymerization, Negative regulation of cytokine activity, and Regulation of white fat cell proliferation. Each is linked with ZEB1 in more than 13 cancer types. Because this analysis shows association rather than direction, both ZEB1-to-partner and partner-to-ZEB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of microtubule depolymerization grouped by ZEB1-low versus ZEB1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZEB1→partner) and Y-score (partner→ZEB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of microtubule depolymerization →	+0.116	+1.476	<.001	.005	3	14
STOMACH	Negative regulation of cytokine activity →	+0.988	+2.823	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Regulation of white fat cell proliferation →	+0.304	+2.164	<.001	<.001	3	13
BONE	Positive regulation of stress fiber assembly →	+0.189	+2.212	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Cellular response to muramyl dipeptide →	+0.214	+2.256	<.001	<.001	3	13
URINARY_TRACT	Establishment of epithelial cell apical/basal polarity →	+0.276	+2.932	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,137 associations by consensus.

Negative regulation of microtubule depolymerization by ZEB1 expression — LUNG_SCLC

Explore this box plot interactively →