ZEB1

Across TCGA cell cohorts, ZEB1 mutation is significantly associated with the RNA expression of many other genes, with 901 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZEB1-associated genes across cancer lineages are KMT5A, LRRC18, and RBMY1F. Each is linked with ZEB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZEB1-to-partner and partner-to-ZEB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT5A grouped by ZEB1-low versus ZEB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZEB1→partner) and Y-score (partner→ZEB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KMT5A →	+0.693	+3.321	.002	.003	3	2
LUNG_SCLC	LRRC18 →	+0.124	+3.523	<.001	.008	3	1
LUNG_SCLC	RBMY1F →	+0.626	+4.058	.001	.007	3	1
BLOOD_Leukemia	OR11H6 →	+0.026	+4.705	<.001	.003	3	1
BLOOD_Leukemia	OR52Z1 →	+0.049	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.096	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 901 associations by consensus.

KMT5A by ZEB1 expression — LARGE_INTESTINE

Explore this box plot interactively →