ZEB1

Across TCGA cell cohorts, ZEB1 mutation is significantly associated with the mutation status of many other genes, with 6,606 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZEB1-associated genes across cancer lineages are TRPC4, GALNT17, and SCN1A. Each is linked with ZEB1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZEB1-to-partner and partner-to-ZEB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPC4 grouped by ZEB1-low versus ZEB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZEB1→partner) and Y-score (partner→ZEB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRPC4 →	+2.413	+2.655	<.001	<.001	1	6
STOMACH	GALNT17 →	+4.807	+4.807	.008	.008	1	5
LARGE_INTESTINE	SCN1A →	+2.050	+2.700	<.001	<.001	1	5
LUNG_NSCLC_LUAD	TENM4 →	+2.478	+3.544	.001	.001	1	4
UPPER_AERODIGESTIVE_TRACT	DMXL1 →	+4.954	+4.392	.008	.008	1	4
SKIN	COL16A1 →	+3.548	+3.210	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,606 associations by consensus.

TRPC4 by ZEB1 expression — LARGE_INTESTINE

Explore this box plot interactively →