ZEB1-AS1

Across TCGA pan-cancer cohorts, ZEB1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ZEB1-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ZEB1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZEB1-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

SKCM, COAD, and ACC are the cancer types where ZEB1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.395	0.271	<.001	94	view →
COAD	OS	Median	All	0.508	0.734	<.001	79	view →
ACC	DFS	Tertile	All	0.508	0.840	<.001	73	view →
LIHC	DFS	Median	All	0.350	0.515	<.001	70	view →
UCS	OS	Tertile	III,IV	0.600	0.155	.003	68	view →
UVM	DFS	Median	III,IV	0.327	0.739	<.001	52	view →
GBM	DFS	Median	All	0.332	0.186	<.001	33	view →
LUAD	DFS	Median	All	0.183	0.445	<.001	33	view →
LGG	OS	Median	All	0.643	0.420	<.001	28	view →
SARC	OS	Quartile	All	0.375	0.729	.005	18	view →
KICH	OS	Quartile	II,III,IV	0.386	1.000	.010	15	view →
LUSC	OS	Median	All	0.812	0.705	.004	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ZEB1-AS1–SKCM (OS)

Open the SKCM breakdown →