ZDHHC8P1

Across TCGA patient cohorts, ZDHHC8P1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC8P1-associated genes across cancer lineages are Chk1_pS345, GAPDH, and ACC1. Each is linked with ZDHHC8P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC8P1-to-partner and partner-to-ZDHHC8P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1_pS345 grouped by ZDHHC8P1-low versus ZDHHC8P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC8P1→partner) and Y-score (partner→ZDHHC8P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk1_pS345 →	-0.170	-3.156	.025	.020	3	2
UCEC	GAPDH →	+0.773	+3.000	.008	.036	3	1
UCEC	ACC1 →	+0.659	+3.169	<.001	.020	3	1
UCEC	JNK2 →	+0.314	+2.817	.004	.036	3	1
UCEC	STAT3_pY705 →	-0.526	-2.990	<.001	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.804	+2.827	.013	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Chk1_pS345 by ZDHHC8P1 expression — UCEC

Explore this box plot interactively →