ZDHHC8

Across TCGA pan-cancer cohorts, ZDHHC8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZDHHC8 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher ZDHHC8 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZDHHC8 expression acts as an unfavorable survival marker.

ESCA, PRAD, and UCEC are the cancer types where ZDHHC8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.163	0.525	.012	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZDHHC8–ESCA (DFS)

Open the ESCA breakdown →