ZDHHC8

Across TCGA patient cohorts, ZDHHC8 mutation is significantly associated with the RNA expression of many other genes, with 1,742 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC8-associated genes across cancer lineages are LINC01831, RNU6-159P, and RNU6-1252P. Each is linked with ZDHHC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZDHHC8-to-partner and partner-to-ZDHHC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01831 grouped by ZDHHC8-low versus ZDHHC8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC8→partner) and Y-score (partner→ZDHHC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC01831 →	+0.085	+4.020	.009	.009	3	3
KIRC	RNU6-159P →	+0.177	+8.025	<.001	.007	3	2
BRCA	RNU6-1252P →	+0.371	+7.731	<.001	.009	3	2
BRCA	RNU11-5P →	+0.311	+7.731	<.001	.009	3	2
BRCA	RN7SL776P →	+0.168	+7.731	<.001	.009	3	2
HNSC	RNU4-26P →	+0.268	+7.954	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,742 associations by consensus.

LINC01831 by ZDHHC8 expression — CESC

Explore this box plot interactively →