ZDHHC8

Across TCGA patient cohorts, ZDHHC8 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC8-associated genes across cancer lineages are Cyclin-E2, ETS-1, and GATA6. Each is linked with ZDHHC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZDHHC8-to-partner and partner-to-ZDHHC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by ZDHHC8-low versus ZDHHC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC8→partner) and Y-score (partner→ZDHHC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.195	+2.222	.006	.011	3	3
SKCM	ETS-1 →	+0.439	+3.000	.003	.034	3	2
UCEC	GATA6 →	-0.147	-2.985	.025	.034	3	2
UCEC	NF-kB-p65_pS536 →	-0.558	-1.990	.003	.030	3	2
UCEC	PDCD4 →	-0.711	-2.906	<.001	.001	3	2
UCEC	PEA-15_pS116 →	+0.392	+1.700	.008	.044	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Cyclin-E2 by ZDHHC8 expression — UCEC

Explore this box plot interactively →