ZDHHC8

Across TCGA cell cohorts, ZDHHC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,060 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZDHHC8-associated GO terms across cancer lineages are Actin filament depolymerization, Protein depolymerization, and Positive regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with ZDHHC8 in more than 15 cancer types. Because this analysis shows association rather than direction, both ZDHHC8-to-partner and partner-to-ZDHHC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by ZDHHC8-low versus ZDHHC8-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC8→partner) and Y-score (partner→ZDHHC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Actin filament depolymerization →	+0.176	+1.896	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein depolymerization →	+0.107	+1.017	<.001	<.001	3	16
LIVER	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.112	+1.336	.001	.002	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.077	+1.020	<.001	<.001	3	14
BONE	Microtubule nucleation →	+0.116	+0.968	<.001	<.001	3	14
OESOPHAGUS	Symbiont-mediated disruption of host cellular anatomical structure →	+0.147	+1.427	.003	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,060 associations by consensus.

Actin filament depolymerization by ZDHHC8 expression — OESOPHAGUS

Explore this box plot interactively →