ZDHHC8

Across TCGA cell cohorts, ZDHHC8 mutation is significantly associated with the RNA expression of many other genes, with 588 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZDHHC8-associated genes across cancer lineages are GSTT4, TCP11X2, and YWHAE. Each is linked with ZDHHC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZDHHC8-to-partner and partner-to-ZDHHC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTT4 grouped by ZDHHC8-low versus ZDHHC8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC8→partner) and Y-score (partner→ZDHHC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSTT4 →	+0.129	+2.681	<.001	.008	3	2
OVARY	TCP11X2 →	+0.323	+3.058	<.001	.004	3	2
LARGE_INTESTINE	YWHAE →	+0.562	+3.743	.002	<.001	3	2
LARGE_INTESTINE	FXR2 →	+0.693	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	CDCA8 →	+0.517	+3.743	.003	<.001	3	2
LARGE_INTESTINE	NEDD1 →	+0.541	+2.628	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 588 associations by consensus.

GSTT4 by ZDHHC8 expression — BLOOD_Leukemia

Explore this box plot interactively →