ZDHHC6

Across TCGA pan-cancer cohorts, ZDHHC6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZDHHC6 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZDHHC6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZDHHC6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where ZDHHC6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	1.000	0.858	.004	29	view →
LUAD	DFS	Median	II,III,IV	0.201	0.798	.001	11	view →
LSCC	DFS	Median	II,III,IV	1.000	0.419	.008	9	view →
PDAC	OS	Quartile	II,III,IV	0.906	0.472	.008	2	view →
CCRCC	DFS	Quartile	III,IV	0.790	0.307	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZDHHC6–HNSC (DFS)

Open the HNSC breakdown →